Therapies make positive impact on Parkinson’s disease
Something positive seems to be coming out for people suffering from Parkinsonâ€™s disease. A latest report by International Stem Cell Corporation says that companyâ€™s therapies seem to have impacted the subjects.
This is among the most important things to have happened when it comes to Parkinsonâ€™s disease and shows that International Stem Cell Corporation seems to have some luck in fighting this disease.
International Stem Cell Corporation presented its data in detail during the 66th American Academy of Neurology Annual Meeting.
International Stem Cell Corporation a California-based biotechnology company developing novel stem cell-based therapies and biomedical products announced today that some behavioral improvements have been observed after six months in the pre-clinical non-human primate (NHP) study of Parkinson’s disease (PD). The detailed behavioral data will be presented at the 66th American Academy of Neurology Annual Meeting in Philadelphia.
“It is encouraging to see these behavioral scores trending in the right direction as it means that the implanted cells may be having a positive impact on the disease symptoms,” said Professor D. Eugene Redmond Jr. MD, of Yale University Medical School and the study’s supervisor. “The rating scores are equivalent to components of the UPDRS which is widely used in research to evaluate Parkinson’s patients. The Parkison’s score is known to correlate very highly with brain dopamine concentrations.”
The study consists of 18 primates, all exposed to the neurotoxin, MPTP, divided into three cohorts, a sham treated group and two treatment groups receiving different doses of human neural stem cells (hPNSC) derived from ISCO’s proprietary parthenogenetic stem cell line. All of the groups had matching levels of parkinsonism and functional disability prior to the cell injections. The 6 months data showed that the healthy behavior scores of the treatment group increased 170% while that of the placebo group increased by 58%. In addition, one of the treatment groups demonstrated a significant improvement in the main Parkinson’s rating score of 63% (p < 0.05) while there was no significant improvement in the control group. The changes in these scores are particularly noteworthy as it signifies a greater reduction in the severity of the symptoms in the treatment group compared with the control group. A more detailed update will be presented once the histopathology and biodistribution analysis of the tissue has been completed.
Dr. Ruslan Semechkin ISCO’s Chief Scientific Officer commented: “The results of this interim analysis are very promising. This study provides information about how our human neural stem cells, derived from our parthenogenetic stem cells, behave in a diseased brain and how the diseased tissue responds and is a critical part of our planned IND submission.”