First Malaria Vaccine May be Closer Than Earlier Estimates
Malaria is among the biggest killers in the world. it kills hundreds of thousands of people in Sub-Saharan Africa and in the Indian Subcontinent. Despite many improvements in medications, the killer disease continues to torment humans in many parts of the world.
But there are reasons to believe that it may be very closed to be tamed. Reports suggest that a vaccine for Malaria may be very close to be launched. This vaccine will help avoids hundreds of unnecesary deaths in many parts of the world.
Reports suggest that the vaccine is undergoing final trials. Malaria vaccine candidate were found to partially protect children against the disease up to four years after vaccination. According to scientists, it may be available by as early as October this year. The results suggest that the vaccine candidate RTS,S/AS01 could prevent a substantial number of cases of clinical malaria, especially in areas of high transmission. “The European Medicines Agency (EMA) will assess the quality, safety, and efficacy of the vaccine based on these final data,” said corresponding author Brian Greenwood, professor at the London School of Hygiene & Tropical Medicine in Britain. “If the EMA gives a favourable opinion, WHO (World Health Organization) could recommend the use of RTS,S/AS01 as early as October this year. If licensed, RTS,S/AS01 would be the first licensed human vaccine against a parasitic disease,” Greenwood added.
It is going to be asort of breakthrough. The findings revealed that vaccine efficacy against clinical and severe malaria was better in children than in young infants, but waned over time in both groups. However, protection was prolonged by a booster dose, increasing the average number of cases prevented in both children and young infants. “Despite the falling efficacy over time, there is still a clear benefit from RTS,S/AS01. An average 1,363 cases of clinical malaria were prevented over four years of follow-up for every 1,000 children vaccinated, and 1,774 cases in those who also received a booster shot. Over three years of follow-up, an average 558 cases were averted for every 1,000 infants vaccinated, and 983 cases in those also given a booster dose,” Greenwood said. “Given that there were an estimated 198 million malaria cases in 2013, this level of efficacy potentially translates into millions of cases of malaria in children being prevented,” suggests Greenwood.
In the meantime the RTS,S/AS01 vaccine was developed for use in sub-Saharan Africa where malaria still kills around 1300 children every day. The phase-3 randomised trial enrolled 15,459 young infants (aged six to 12 weeks at first vaccination) and children (five to 17 months at first vaccination) from 11 sites across seven sub-Saharan African countries (Burkina Faso, Gabon, Ghana, Kenya, Malawi, Mozambique and United Republic of Tanzania) with varying levels of malaria transmission. In 2014, initial phase-3 results at 18 months showed vaccine efficacy of about 46 percent against clinical malaria in children and around 27 percent among young infants. There is currently no licensed vaccine against malaria anywhere in the world. These findings were published in the journal The Lancet.
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